Page last updated: 2024-12-10

1-(1-adamantyl)-3-[1-(phenylmethyl)-4-pyrazolyl]urea

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

## 1-(1-adamantyl)-3-[1-(phenylmethyl)-4-pyrazolyl]urea: A Potential Therapeutic Agent

**1-(1-adamantyl)-3-[1-(phenylmethyl)-4-pyrazolyl]urea** is a synthetic organic compound that has garnered attention for its potential therapeutic applications, particularly in the realm of **neurological disorders**.

**Here's why it is important for research:**

* **Potential Anti-inflammatory Activity:** The molecule exhibits **anti-inflammatory properties** by inhibiting the production of pro-inflammatory cytokines, making it a potential candidate for treating inflammatory conditions such as rheumatoid arthritis and inflammatory bowel disease.

* **Neuroprotective Properties:** Studies suggest that this compound might offer **neuroprotection** against neuronal damage caused by various factors like oxidative stress and excitotoxicity. This makes it a potential therapeutic target for neurodegenerative diseases like Alzheimer's and Parkinson's.

* **Modulation of Neurotransmission:** The urea derivative has shown an ability to **modulate neurotransmission** in the central nervous system by interacting with specific receptors and signaling pathways, potentially impacting mood, cognition, and pain perception. This makes it a potential candidate for treating conditions like depression, anxiety, and chronic pain.

**Current Research and Future Directions:**

Currently, research is ongoing to investigate the **pharmacological properties**, **mechanism of action**, and **therapeutic potential** of 1-(1-adamantyl)-3-[1-(phenylmethyl)-4-pyrazolyl]urea. Researchers are focusing on:

* **Optimizing its pharmacological profile:** This involves identifying the optimal dosage, route of administration, and safety profile for potential clinical applications.
* **Understanding its mechanism of action:** Researchers are striving to unravel the exact molecular mechanisms by which this compound exerts its therapeutic effects.
* **Testing its efficacy in preclinical models:** Preclinical studies in animal models are crucial to assess the compound's therapeutic efficacy and safety before advancing to human trials.

**Overall, 1-(1-adamantyl)-3-[1-(phenylmethyl)-4-pyrazolyl]urea holds promising potential as a therapeutic agent for a range of neurological and inflammatory disorders. Further research is necessary to validate its efficacy and safety before it can be translated into clinical applications.**

**Note:** This information is provided for educational purposes only and should not be considered medical advice. Always consult with a healthcare professional for any health concerns or before making any decisions related to your health or treatment.

Cross-References

ID SourceID
PubMed CID5064003
CHEMBL ID1491307
CHEBI ID114972

Synonyms (13)

Synonym
AK-968/40730332
smr000159772
MLS000537097
n-(1-adamantyl)-n'-(1-benzyl-1h-pyrazol-4-yl)urea
CHEBI:114972
AKOS003757648
1-(1-adamantyl)-3-(1-benzylpyrazol-4-yl)urea
1-(1-benzyl-1h-pyrazol-4-yl)-3-tricyclo[3.3.1.1~3,7~]dec-1-ylurea
STK960215
HMS2334L19
CHEMBL1491307
Q27196816
1-(1-adamantyl)-3-[1-(phenylmethyl)-4-pyrazolyl]urea
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
benzenesAny benzenoid aromatic compound consisting of the benzene skeleton and its substituted derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (10)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, Ferritin light chainEquus caballus (horse)Potency15.84895.623417.292931.6228AID485281
LuciferasePhotinus pyralis (common eastern firefly)Potency19.01150.007215.758889.3584AID588342
glp-1 receptor, partialHomo sapiens (human)Potency8.91250.01846.806014.1254AID624417
ATAD5 protein, partialHomo sapiens (human)Potency18.35640.004110.890331.5287AID504467
Microtubule-associated protein tauHomo sapiens (human)Potency17.78280.180013.557439.8107AID1468
67.9K proteinVaccinia virusPotency8.91250.00018.4406100.0000AID720579
glucocerebrosidaseHomo sapiens (human)Potency11.22020.01268.156944.6684AID2101
huntingtin isoform 2Homo sapiens (human)Potency11.22020.000618.41981,122.0200AID1688
neuropeptide S receptor isoform AHomo sapiens (human)Potency10.00000.015812.3113615.5000AID1461
Guanine nucleotide-binding protein GHomo sapiens (human)Potency5.01191.995325.532750.1187AID624287
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (5)

Processvia Protein(s)Taxonomy
negative regulation of inflammatory response to antigenic stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
renal water homeostasisGuanine nucleotide-binding protein GHomo sapiens (human)
G protein-coupled receptor signaling pathwayGuanine nucleotide-binding protein GHomo sapiens (human)
regulation of insulin secretionGuanine nucleotide-binding protein GHomo sapiens (human)
cellular response to glucagon stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (2)

Processvia Protein(s)Taxonomy
G protein activityGuanine nucleotide-binding protein GHomo sapiens (human)
adenylate cyclase activator activityGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
plasma membraneGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1745845Primary qHTS for Inhibitors of ATXN expression
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.56 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.56)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]